Scientific production

Recommendations for standardizing nomenclature for dietary (poly)phenol catabolites

The American Journal of Clinical Nutrition 

Colin D Kay; Michael N Clifford; Pedro Mena; Gordon J McDougall; Cristina Andres-Lacueva; Aedin Cassidy; Daniele Del Rio; Nikolai Kuhnert; Claudine Manach; Gema Pereira-Caro; Ana Rodriguez-Mateos; Augustin Scalbert; Francisco Tomás-Barberán; Gary Williamson; David S Wishart; Alan Crozier

There is a lack of focus on the protective health effects of phytochemicals in dietary guidelines. Although a number of chemical libraries and databases contain dietary phytochemicals belonging to the plant metabolome, they are not entirely relevant to human health because many constituents are extensively metabolized within the body following ingestion. This is especially apparent for the highly abundant dietary (poly)phenols, for which the situation is compounded by confusion regarding their bioavailability and metabolism, partially because of the variety of nomenclatures and trivial names used to describe compounds arising from microbial catabolism in the gastrointestinal tract. This confusion, which is perpetuated in online chemical/metabolite databases, will hinder future discovery of bioactivities and affect the establishment of future dietary guidelines if steps are not taken to overcome these issues. In order to resolve this situation, a nomenclature system for phenolic catabolites and their human phase II metabolites is proposed in this article and the basis of its format outlined. Previous names used in the literature are cited along with the recommended nomenclature, International Union of Pure and Applied Chemistry terminology, and, where appropriate, Chemical Abstracts Service numbers, InChIKey, and accurate mass.

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Biomarkers of Nutrition and Health: New Tools for New Approaches

Nutrients Journal

Catalina Picó; Francisca Serra; Ana María Rodríguez; Andreu Palou; Jaap Keijer

A main challenge in nutritional studies is the valid and reliable assessment of food intake, as well as its effects on the body. Generally, food intake measurement is based on self-reported dietary intake questionnaires, which have inherent limitations. They can be overcome by the use of biomarkers, capable of objectively assessing food consumption without the bias of self-reported dietary assessment. Another major goal is to determine the biological effects of foods and their impact on health. Systems analysis of dynamic responses may help to identify biomarkers indicative of intake and effects on the body at the same time, possibly in relation to individuals’ health/disease states. Such biomarkers could be used to quantify intake and validate intake questionnaires, analyse physiological or pathological responses to certain food components or diets, identify persons with specific dietary deficiency, provide information on inter-individual variations or help to formulate personalized dietary recommendations to achieve optimal health for particular phenotypes, currently referred as “precision nutrition.” In this regard, holistic approaches using global analysis methods (omics approaches), capable of gathering high amounts of data, appear to be very useful to identify new biomarkers and to enhance our understanding of the role of food in health and disease.

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A systematic review of the cost-effectiveness of personalised interventions with a nutrition component in adults

ISPOR Conference (ISPOR)

Milanne Galekop(Ken) WK Redekop(Carin) CA Uyl – de Groot

Poster describeing the systematic literature review performed in the PREVENTOMICS project to establish what has already been done in personalised nutrition interventions and identify important gaps in literature.

This review will be used to design cross-sectional surveys and produce cost-effectiveness analyses to assess the efficiency of the PREVENTOMICS solution versus the current and alternative tools and assess its health outcomes and costs.

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